15 g daily away from slimming down K + intake sustained to possess 20 days (20, 43). Current conclusions (talked about below) possess identified the clear presence of an enthusiastic enteric K + sensing apparatus one to initiates brand new renal secretory process upon K + admission towards the digestion. The fresh new distal convoluted tubule has been identified as a web page vital to possess K + homeostasis, in which it acts as an effective K + sensor capable of opening K + excretion independent away from mineralocorticoid craft.
Report on Renal K + Addressing
K + was easily filtered along the glomerulus then avidly reabsorbed by the latest fabswingers proximal tubule and you can heavy ascending limb of the kidney. K + reabsorption regarding proximal tubule is mainly from paracellular path and is within the crude ratio into level of Na + and you will liquid reabsorbed (Fig. 1). Regarding the dense rising limb, K + reabsorption happen of the each other transcellular and you can paracellular pathways. Transcellular movement are mediated by the Na + -K + -2Cl ? cotransporter located on the apical membrane layer. A component of K + one to gets in the cell back diffuses for the lumen from the ROMK (renal external medullary K + ) station, leading to the fresh generation regarding a beneficial lumen positive costs and this, consequently, drives a component of K + reabsorption through the paracellular pathway (Fig. 2). K + secretion begins inside the early distal convoluted tubule and you can increasingly expands from inside the magnitude to the cortical event duct. Mental means handle this new secretory element of K + handling (36).
Fig. step 1.A big element of filtered K + are reabsorbed of the proximal tubule primarily from the paracellular pathway driven from the solvent drag. This new change inside the lumen potential out-of negative to positive regarding later servings of the proximal tubule provides an extra driving force to possess K + reabsorption. Read more
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