Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physical plans and pharmacology of curcumin
Publication ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin ‘s the biggest element of the new purple color of turmeric, a keen Indian spice that is taken from the brand new rhizome of your own exotic plant Curcuma longa, and this belongs to the Zingiberaceae nearest and dearest. Within part, i discuss the pharmacological things from curcumin and you can mention the brand new unit basics of these items. We next opinion the latest confirmed and you can potential logical uses out of curcumin. Curcumin is well known historically while the a restorative representative, but the method out of step are detail by detail. The fresh new pharmacological aftereffects of curcumin seem to be the consequence of a synergism out-of networks out-of weakened biochemical relations having multiple physiological goals inside the interrelated signaling paths. These objectives are enzymes such as for instance cyclooxygenase, lipoxygenase and you may healthy protein kinases, and transcription points instance NF-?B, STAT and you can Nrf2. Modulation of them particles influences downstream affectors that make the latest antiinflammatory, antioxidant, chemopreventive, anticancer, and you may antimicrobial products away from curcumin. These types of effects were tested for the medical examples away from curcumin getting problems and you will inflammatory infection, cancer tumors, Alzheimer problem, cardio disease, and you may all forms of diabetes. New samples purchased adjustable doses from curcuminwith other wavelengths and you can cycle, toward standard completion one to large dosages off curcumin within quantity of grams have to see healing effects. Find out more
Curcumin: Synthesis, Growing Role in Discomfort Administration and you can Fitness Effects
Book Part Types of bush-derived pharmaceuticals with get to be the notice of continuous and you can great look and you can development interest possess, yet, been quite scarce. Immediately after several years, the Polska kvinnor dejta past 20 years was in fact described as a good 100-fold increase in what number of scientific stuff published a-year that is of significance towards accessibility curcumin during the biomedicine. Find out more
Structure, synthesis and you may physical products out-of curcumin prodrugs
Publication ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin has many prospective pharmacological consequences that will possess therapeutic software in lot of situation says, since talked about in detail in the previous section. But not, the possibility systematic efficacy away from curcumin is restricted from the the physicochemical features of bad liquids solubility and instability, which produce lowest bioavailability. Prodrugs away from curcumin promote a means to improvement of biopharmaceutical and you can pharmacokinetic functions, and can even allow it to be exploitation of pharmacological ramifications of curcumin. Within this section, we first comment the newest physicochemical and you can pharmacokinetics out of curcumin. I following identify the style of curcumin prodrugs with improved liquids solubility and increased chemical balance that can easily be translated to 100 % free curcumin on bioactivation in the vivo. We high light previous victory in this field, with a focus on the design, synthesis and you may testing off prodrugs predicated on promoieties and proteins, essential fatty acids, nucleic acids, dicarboxylic acids, and you may polymeric information particularly hyaluronic acidic and you will polyethylene glycol. It part gets the cause for optimisation of your own physicochemical and biopharmaceutical features and also the physical circumstances of curcumin prodrugs, for the mission having fun with of these curcumin types for the health-related programs. Find out more